2025
Journal article
Open Access
Challenges in using pupil dilation responses to sounds as a reliable alternative to standard audiometric tests
Tramonti Fantozzi M. P., Crivello A., La Rosa D., Milazzo M., Danti S., De Cicco V., Orsini P., Manzoni D., Lazzerini F., Canelli R., Fiacchini G., Bruschini L.
Audiometry Pupillometry Orienting reflex Pupil dilatation Research Article Auditory detection
Assessing hearing in neonates and uncooperative patients can be challenging. Pupil dilation response (PDR) as an objective physiological measure may offer a solution. To test its feasibility, PDRs were averaged in response to a sequence of 60–100 audible tones (same frequency and amplitude). This was performed in subjects with normal hearing and communication abilities, who were exposed to two different lighting levels. We evaluated whether averaged post-stimulus intervals of PDRs were significantly different from randomly generated averages of pupil traces recorded in the absence of sound stimulation from the same subject. This analysis was repeated for the first, second, and third block of PDRs to account for possible adaptation phenomena. Although all the participants clearly perceived the tones, significant PDRs in response to sound were only detected in a fraction of subjects, primarily in the low luminance condition. Consequently, only in the low luminance group, the grand average of individual PDRs was significantly larger than that obtained for traces recorded in the absence of sound input. In this most favorable condition, when the three blocks of PDRs were averaged separately, significant PDRs were observed in 40 % of the subjects in at least one of the blocks. Therefore, the PDR to sound input is not a reliable indicator of hearing perception when standard audiometric stimuli of the same amplitude and frequency are used. Possible modifications to sound input and stimulation protocols for obtaining reliable PDRs in diagnosing and treating hearing impairments are discussed.
Source: HELIYON, vol. 11 (issue 4)
James, A.L., Osborn, H.A., Osman, H., Papaioannou, V., Gordon, K.A.. The limitation of risk factors as a means of prognostication in auditory neuropathy spectrum disorder of perinatal onset. Int. J. Pediatr. Otorhinolaryngol.. 2020; 135
Fan, H., Li, D., Wang, S., Kong, W.. Preoperative factors influencing the rate and speed of available communication ability in prelingual paediatric cochlear implantation recipients. Acta Otolaryngol.. 2023: 1-8
Forli, F., Bruschini, L., Franciosi, B., Berrettini, S., Lazzerini, F.. Sequential bilateral cochlear implant: long-term speech perception results in children first implanted at an early age. Eur. Arch. Otorhinolaryngol.. 2023; 280: 1073-1080
McClannahan, K.S., Chiu, Y.-F., Sommers, M.S., Peelle, J.E.. Test-retest reliability of audiometric assessment in individuals with mild dementia. JAMA Otolaryngol.--Head & Neck Surg.. 2021; 147: 442-449
Bott, A., Meyer, C., Hickson, L., Pachana, N.A.. Can adults living with dementia complete pure-tone audiometry? A systematic review. Int. J. Audiol.. 2019; 58: 185-192
Legatt, A.D.. Electrophysiologic auditory tests. Handb. Clin. Neurol.. 2015; 129: 289-311
Sokolov, E.N.. Higher nervous functions: the orienting reflex. Annu. Rev. Physiol.. 1963; 25: 545-580
Marois, A., Labonté, K., Parent, M., Vachon, F.. Eyes have ears: indexing the orienting response to sound using pupillometry. Int. J. Psychophysiol.. 2018; 123: 152-162
Zekveld, A.A., Koelewijn, T., Kramer, S.E.. The pupil dilation response to auditory stimuli: current state of knowledge. Trends Hear. 2018; 22
Kramer, S.E., Lorens, A., Coninx, F., Zekveld, A.A., Piotrowska, A., Skarzynski, H.. Processing load during listening: the influence of task characteristics on the pupil response. Lang. Cognit. Process.. 2013; 28: 426-442
Eklöf, M., Asp, F., Berninger, E.. Sound localization latency in normal hearing and simulated unilateral hearing loss. Hear. Res.. 2020; 395
Naylor, G., Koelewijn, T., Zekveld, A.A., Kramer, S.E.. The application of pupillometry in hearing science to assess listening effort. Trends Hear. 2018; 22
Kramer, S.E., Kapteyn, T.S., Festen, J.M., Kuik, D.J.. Assessing aspects of auditory handicap by means of pupil dilatation. Audiology. 1997; 36: 155-164
Bala, A.D.S., Takahashi, T.T.. Pupillary dilation response as an indicator of auditory discrimination in the barn owl. J. Comp. Physiol.. 2000; 186: 425-434
Montes-Lourido, P., Kar, M., Kumbam, I., Sadagopan, S.. Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models. Sci. Rep.. 2021; 11: 3108
Liao, H.-I., Kidani, S., Yoneya, M., Kashino, M., Furukawa, S.. Correspondences among pupillary dilation response, subjective salience of sounds, and loudness. Psychon. Bull. Rev.. 2016; 23: 412-425
Bala, A.D.S., Whitchurch, E.A., Takahashi, T.T.. Human auditory detection and discrimination measured with the pupil dilation response. J. Assoc. Res. Otolaryngol.. 2020; 21: 43-59
Selezneva, E., Brosch, M., Rathi, S., Vighneshvel, T., Wetzel, N.. Comparison of pupil dilation responses to unexpected sounds in monkeys and humans. Front. Psychol.. 2021; 12
Kleberg, J.L., Del Bianco, T., Falck-Ytter, T.. How infants' arousal influences their visual search. Child Dev.. 2019; 90: 1413-1423
Rudling, M., Nyström, P., Bölte, S., Falck-Ytter, T.. Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis. JCPP. 2022; 63: 793-801
Wetzel, N., Buttelmann, D., Schieler, A., Widmann, A.. Infant and adult pupil dilation in response to unexpected sounds. Dev. Psychobiol.. 2016; 58: 382-392
Bonmassar, C., Widmann, A., Wetzel, N.. The impact of novelty and emotion on attention-related neuronal and pupil responses in children. Dev Cogn Neurosci. 2020; 42
Fletcher, P.D., Nicholas, J.M., Shakespeare, T.J., Downey, L.E., Golden, H.L., Agustus, J.L., Clark, C.N., Mummery, C.J., Schott, J.M., Crutch, S.J.. others, Physiological phenotyping of dementias using emotional sounds. Alzheim. Dement.: Diagn., Assess. Dis. Monit.. 2015; 1: 170-178
Fletcher, P.D., Nicholas, J.M., Shakespeare, T.J., Downey, L.E., Golden, H.L., Agustus, J.L., Clark, C.N., Mummery, C.J., Schott, J.M., Crutch, S.J.. others, Dementias show differential physiological responses to salient sounds. Front. Behav. Neurosci.. 2015; 9: 73
Fletcher, P.D., Nicholas, J.M., Downey, L.E., Golden, H.L., Clark, C.N., Pires, C., Agustus, J.L., Mummery, C.J., Schott, J.M., Rohrer, others, J.D.. A physiological signature of sound meaning in dementia. Cortex. 2016; 77: 13-23
La Rosa, D., Bruschini, L., Tramonti Fantozzi, M.P., Orsini, P., Milazzo, M., Crivello, A.. Pupil data upon stimulation by auditory stimuli. Data (Basel). 2024; 9: 43
Steiger, J.H.. Tests for comparing elements of a correlation matrix. Psychol. Bull.. 1980; 87: 245
Cohen, J., Cohen, P., West, S.G., Aiken, L.S.. 2013
Viglione, A., Mazziotti, R., Pizzorusso, T.. From pupil to the brain: new insights for studying cortical plasticity through pupillometry. Front Neural Circ.. 2023; 17
Hakerem, G.A.D., Sutton, S.. Pupillary response at visual threshold. Nature. 1966
Kronemer, S.I., Aksen, M., Ding, J.Z., Ryu, J.H., Xin, Q., Ding, Z., Prince, J.S., Kwon, H., Khalaf, A., Forman, S., others, null. Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity. Nat. Commun.. 2022; 13: 7342
Aston-Jones, G., Cohen, J.D.. An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu. Rev. Neurosci.. 2005; 28: 403-450
Loewenfeld, I.E., Lowenstein, O.. 1999
Steinhauer, S.R., Siegle, G.J., Condray, R., Pless, M.. Sympathetic and parasympathetic innervation of pupillary dilation during sustained processing. Int. J. Psychophysiol.. 2004; 52: 77-86
Wang, C.-A., Munoz, D.P.. Neural basis of location-specific pupil luminance modulation. Proc. Natl. Acad. Sci. USA. 2018; 115: 10446-10451
Marg, E., Morgan, M.W.. The pupillary near reflex; the relation of pupillary diameter to accommodation and the various components of convergence. Optom. Vis. Sci.. 1949; 26: 183-198
[1] A.L. James, H.A. Osborn, H. Osman, V. Papaioannou, K.A. Gordon, The limitation of risk factors as a means of prognostication in auditory neuropathy spectrum disorder of perinatal onset, Int. J. Pediatr. Otorhinolaryngol. 135 (2020) 110112.
[2] H. Fan, D. Li, S. Wang, W. Kong, Preoperative factors influencing the rate and speed of available communication ability in prelingual paediatric cochlear implantation recipients, Acta Otolaryngol. (2023) 1-8.
[3] F. Forli, L. Bruschini, B. Franciosi, S. Berrettini, F. Lazzerini, Sequential bilateral cochlear implant: long-term speech perception results in children first implanted at an early age, Eur. Arch. Otorhinolaryngol. 280 (2023) 1073-1080.
[4] K.S. McClannahan, Y.-F. Chiu, M.S. Sommers, J.E. Peelle, Test-retest reliability of audiometric assessment in individuals with mild dementia, JAMA Otolaryngol.-Head & Neck Surg. 147 (2021) 442-449.
[5] A. Bott, C. Meyer, L. Hickson, N.A. Pachana, Can adults living with dementia complete pure-tone audiometry? A systematic review, Int. J. Audiol. 58 (2019) 185-192.
[6] A.D. Legatt, Electrophysiologic auditory tests, Handb. Clin. Neurol. 129 (2015) 289-311.
[7] E.N. Sokolov, Higher nervous functions: the orienting reflex, Annu. Rev. Physiol. 25 (1963) 545-580.
[8] A. Marois, K. Labonte´, M. Parent, F. Vachon, Eyes have ears: indexing the orienting response to sound using pupillometry, Int. J. Psychophysiol. 123 (2018) 152-162.
[9] A.A. Zekveld, T. Koelewijn, S.E. Kramer, The pupil dilation response to auditory stimuli: current state of knowledge, Trends Hear 22 (2018) 2331216518777174.
[10] S.E. Kramer, A. Lorens, F. Coninx, A.A. Zekveld, A. Piotrowska, H. Skarzynski, Processing load during listening: the influence of task characteristics on the pupil response, Lang. Cognit. Process. 28 (2013) 426-442.
[11] M. Eklo¨f, F. Asp, E. Berninger, Sound localization latency in normal hearing and simulated unilateral hearing loss, Hear. Res. 395 (2020) 108011.
[12] G. Naylor, T. Koelewijn, A.A. Zekveld, S.E. Kramer, The application of pupillometry in hearing science to assess listening effort, Trends Hear 22 (2018) 2331216518799437.
[13] S.E. Kramer, T.S. Kapteyn, J.M. Festen, D.J. Kuik, Assessing aspects of auditory handicap by means of pupil dilatation, Audiology 36 (1997) 155-164.
[14] A.D.S. Bala, T.T. Takahashi, Pupillary dilation response as an indicator of auditory discrimination in the barn owl, J. Comp. Physiol. 186 (2000) 425-434.
[15] P. Montes-Lourido, M. Kar, I. Kumbam, S. Sadagopan, Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models, Sci. Rep. 11 (2021) 3108.
[16] H.-I. Liao, S. Kidani, M. Yoneya, M. Kashino, S. Furukawa, Correspondences among pupillary dilation response, subjective salience of sounds, and loudness, Psychon. Bull. Rev. 23 (2016) 412-425.
[17] A.D.S. Bala, E.A. Whitchurch, T.T. Takahashi, Human auditory detection and discrimination measured with the pupil dilation response, J. Assoc. Res. Otolaryngol. 21 (2020) 43-59.
[18] E. Selezneva, M. Brosch, S. Rathi, T. Vighneshvel, N. Wetzel, Comparison of pupil dilation responses to unexpected sounds in monkeys and humans, Front. Psychol. 12 (2021) 754604.
[19] J.L. Kleberg, T. Del Bianco, T. Falck-Ytter, How infants' arousal influences their visual search, Child Dev. 90 (2019) 1413-1423.
[20] M. Rudling, P. Nystro¨m, S. Bo¨lte, T. Falck-Ytter, Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis, JCPP 63 (2022) 793-801.
[21] N. Wetzel, D. Buttelmann, A. Schieler, A. Widmann, Infant and adult pupil dilation in response to unexpected sounds, Dev. Psychobiol. 58 (2016) 382-392.
[22] C. Bonmassar, A. Widmann, N. Wetzel, The impact of novelty and emotion on attention-related neuronal and pupil responses in children, Dev Cogn Neurosci 42 (2020) 100766.
[23] P.D. Fletcher, J.M. Nicholas, T.J. Shakespeare, L.E. Downey, H.L. Golden, J.L. Agustus, C.N. Clark, C.J. Mummery, J.M. Schott, S.J. Crutch, others, Physiological phenotyping of dementias using emotional sounds, Alzheim. Dement.: Diagn., Assess. Dis. Monit. 1 (2015) 170-178.
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[26] D. La Rosa, L. Bruschini, M.P. Tramonti Fantozzi, P. Orsini, M. Milazzo, A. Crivello, Pupil data upon stimulation by auditory stimuli, Data (Basel) 9 (2024) 43.
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[31] S.I. Kronemer, M. Aksen, J.Z. Ding, J.H. Ryu, Q. Xin, Z. Ding, J.S. Prince, H. Kwon, A. Khalaf, S. Forman, others, Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity, Nat. Commun. 13 (2022) 7342.
[32] G. Aston-Jones, J.D. Cohen, An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance, Annu. Rev. Neurosci. 28 (2005) 403-450.
[33] I.E. Loewenfeld, O. Lowenstein, The Pupil: Anatomy, Physiology, and Clinical Applications, 1999.
[34] S.R. Steinhauer, G.J. Siegle, R. Condray, M. Pless, Sympathetic and parasympathetic innervation of pupillary dilation during sustained processing, Int. J. Psychophysiol. 52 (2004) 77-86.
[35] C.-A. Wang, D.P. Munoz, Neural basis of location-specific pupil luminance modulation, Proc. Natl. Acad. Sci. USA 115 (2018) 10446-10451.
[36] E. Marg, M.W. Morgan Jr., The pupillary near reflex; the relation of pupillary diameter to accommodation and the various components of convergence, Optom. Vis. Sci. 26 (1949) 183-198.
Fan, H., Li, D., Wang, S., Kong, W.. Preoperative factors influencing the rate and speed of available communication ability in prelingual paediatric cochlear implantation recipients. Acta Otolaryngol.. 2023: 1-8
Forli, F., Bruschini, L., Franciosi, B., Berrettini, S., Lazzerini, F.. Sequential bilateral cochlear implant: long-term speech perception results in children first implanted at an early age. Eur. Arch. Otorhinolaryngol.. 2023; 280: 1073-1080
McClannahan, K.S., Chiu, Y.-F., Sommers, M.S., Peelle, J.E.. Test-retest reliability of audiometric assessment in individuals with mild dementia. JAMA Otolaryngol.--Head & Neck Surg.. 2021; 147: 442-449
Bott, A., Meyer, C., Hickson, L., Pachana, N.A.. Can adults living with dementia complete pure-tone audiometry? A systematic review. Int. J. Audiol.. 2019; 58: 185-192
Legatt, A.D.. Electrophysiologic auditory tests. Handb. Clin. Neurol.. 2015; 129: 289-311
Sokolov, E.N.. Higher nervous functions: the orienting reflex. Annu. Rev. Physiol.. 1963; 25: 545-580
Marois, A., Labonté, K., Parent, M., Vachon, F.. Eyes have ears: indexing the orienting response to sound using pupillometry. Int. J. Psychophysiol.. 2018; 123: 152-162
Zekveld, A.A., Koelewijn, T., Kramer, S.E.. The pupil dilation response to auditory stimuli: current state of knowledge. Trends Hear. 2018; 22
Kramer, S.E., Lorens, A., Coninx, F., Zekveld, A.A., Piotrowska, A., Skarzynski, H.. Processing load during listening: the influence of task characteristics on the pupil response. Lang. Cognit. Process.. 2013; 28: 426-442
Eklöf, M., Asp, F., Berninger, E.. Sound localization latency in normal hearing and simulated unilateral hearing loss. Hear. Res.. 2020; 395
Naylor, G., Koelewijn, T., Zekveld, A.A., Kramer, S.E.. The application of pupillometry in hearing science to assess listening effort. Trends Hear. 2018; 22
Kramer, S.E., Kapteyn, T.S., Festen, J.M., Kuik, D.J.. Assessing aspects of auditory handicap by means of pupil dilatation. Audiology. 1997; 36: 155-164
Bala, A.D.S., Takahashi, T.T.. Pupillary dilation response as an indicator of auditory discrimination in the barn owl. J. Comp. Physiol.. 2000; 186: 425-434
Montes-Lourido, P., Kar, M., Kumbam, I., Sadagopan, S.. Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models. Sci. Rep.. 2021; 11: 3108
Liao, H.-I., Kidani, S., Yoneya, M., Kashino, M., Furukawa, S.. Correspondences among pupillary dilation response, subjective salience of sounds, and loudness. Psychon. Bull. Rev.. 2016; 23: 412-425
Bala, A.D.S., Whitchurch, E.A., Takahashi, T.T.. Human auditory detection and discrimination measured with the pupil dilation response. J. Assoc. Res. Otolaryngol.. 2020; 21: 43-59
Selezneva, E., Brosch, M., Rathi, S., Vighneshvel, T., Wetzel, N.. Comparison of pupil dilation responses to unexpected sounds in monkeys and humans. Front. Psychol.. 2021; 12
Kleberg, J.L., Del Bianco, T., Falck-Ytter, T.. How infants' arousal influences their visual search. Child Dev.. 2019; 90: 1413-1423
Rudling, M., Nyström, P., Bölte, S., Falck-Ytter, T.. Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis. JCPP. 2022; 63: 793-801
Wetzel, N., Buttelmann, D., Schieler, A., Widmann, A.. Infant and adult pupil dilation in response to unexpected sounds. Dev. Psychobiol.. 2016; 58: 382-392
Bonmassar, C., Widmann, A., Wetzel, N.. The impact of novelty and emotion on attention-related neuronal and pupil responses in children. Dev Cogn Neurosci. 2020; 42
Fletcher, P.D., Nicholas, J.M., Shakespeare, T.J., Downey, L.E., Golden, H.L., Agustus, J.L., Clark, C.N., Mummery, C.J., Schott, J.M., Crutch, S.J.. others, Physiological phenotyping of dementias using emotional sounds. Alzheim. Dement.: Diagn., Assess. Dis. Monit.. 2015; 1: 170-178
Fletcher, P.D., Nicholas, J.M., Shakespeare, T.J., Downey, L.E., Golden, H.L., Agustus, J.L., Clark, C.N., Mummery, C.J., Schott, J.M., Crutch, S.J.. others, Dementias show differential physiological responses to salient sounds. Front. Behav. Neurosci.. 2015; 9: 73
Fletcher, P.D., Nicholas, J.M., Downey, L.E., Golden, H.L., Clark, C.N., Pires, C., Agustus, J.L., Mummery, C.J., Schott, J.M., Rohrer, others, J.D.. A physiological signature of sound meaning in dementia. Cortex. 2016; 77: 13-23
La Rosa, D., Bruschini, L., Tramonti Fantozzi, M.P., Orsini, P., Milazzo, M., Crivello, A.. Pupil data upon stimulation by auditory stimuli. Data (Basel). 2024; 9: 43
Steiger, J.H.. Tests for comparing elements of a correlation matrix. Psychol. Bull.. 1980; 87: 245
Cohen, J., Cohen, P., West, S.G., Aiken, L.S.. 2013
Viglione, A., Mazziotti, R., Pizzorusso, T.. From pupil to the brain: new insights for studying cortical plasticity through pupillometry. Front Neural Circ.. 2023; 17
Hakerem, G.A.D., Sutton, S.. Pupillary response at visual threshold. Nature. 1966
Kronemer, S.I., Aksen, M., Ding, J.Z., Ryu, J.H., Xin, Q., Ding, Z., Prince, J.S., Kwon, H., Khalaf, A., Forman, S., others, null. Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity. Nat. Commun.. 2022; 13: 7342
Aston-Jones, G., Cohen, J.D.. An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu. Rev. Neurosci.. 2005; 28: 403-450
Loewenfeld, I.E., Lowenstein, O.. 1999
Steinhauer, S.R., Siegle, G.J., Condray, R., Pless, M.. Sympathetic and parasympathetic innervation of pupillary dilation during sustained processing. Int. J. Psychophysiol.. 2004; 52: 77-86
Wang, C.-A., Munoz, D.P.. Neural basis of location-specific pupil luminance modulation. Proc. Natl. Acad. Sci. USA. 2018; 115: 10446-10451
Marg, E., Morgan, M.W.. The pupillary near reflex; the relation of pupillary diameter to accommodation and the various components of convergence. Optom. Vis. Sci.. 1949; 26: 183-198
[1] A.L. James, H.A. Osborn, H. Osman, V. Papaioannou, K.A. Gordon, The limitation of risk factors as a means of prognostication in auditory neuropathy spectrum disorder of perinatal onset, Int. J. Pediatr. Otorhinolaryngol. 135 (2020) 110112.
[2] H. Fan, D. Li, S. Wang, W. Kong, Preoperative factors influencing the rate and speed of available communication ability in prelingual paediatric cochlear implantation recipients, Acta Otolaryngol. (2023) 1-8.
[3] F. Forli, L. Bruschini, B. Franciosi, S. Berrettini, F. Lazzerini, Sequential bilateral cochlear implant: long-term speech perception results in children first implanted at an early age, Eur. Arch. Otorhinolaryngol. 280 (2023) 1073-1080.
[4] K.S. McClannahan, Y.-F. Chiu, M.S. Sommers, J.E. Peelle, Test-retest reliability of audiometric assessment in individuals with mild dementia, JAMA Otolaryngol.-Head & Neck Surg. 147 (2021) 442-449.
[5] A. Bott, C. Meyer, L. Hickson, N.A. Pachana, Can adults living with dementia complete pure-tone audiometry? A systematic review, Int. J. Audiol. 58 (2019) 185-192.
[6] A.D. Legatt, Electrophysiologic auditory tests, Handb. Clin. Neurol. 129 (2015) 289-311.
[7] E.N. Sokolov, Higher nervous functions: the orienting reflex, Annu. Rev. Physiol. 25 (1963) 545-580.
[8] A. Marois, K. Labonte´, M. Parent, F. Vachon, Eyes have ears: indexing the orienting response to sound using pupillometry, Int. J. Psychophysiol. 123 (2018) 152-162.
[9] A.A. Zekveld, T. Koelewijn, S.E. Kramer, The pupil dilation response to auditory stimuli: current state of knowledge, Trends Hear 22 (2018) 2331216518777174.
[10] S.E. Kramer, A. Lorens, F. Coninx, A.A. Zekveld, A. Piotrowska, H. Skarzynski, Processing load during listening: the influence of task characteristics on the pupil response, Lang. Cognit. Process. 28 (2013) 426-442.
[11] M. Eklo¨f, F. Asp, E. Berninger, Sound localization latency in normal hearing and simulated unilateral hearing loss, Hear. Res. 395 (2020) 108011.
[12] G. Naylor, T. Koelewijn, A.A. Zekveld, S.E. Kramer, The application of pupillometry in hearing science to assess listening effort, Trends Hear 22 (2018) 2331216518799437.
[13] S.E. Kramer, T.S. Kapteyn, J.M. Festen, D.J. Kuik, Assessing aspects of auditory handicap by means of pupil dilatation, Audiology 36 (1997) 155-164.
[14] A.D.S. Bala, T.T. Takahashi, Pupillary dilation response as an indicator of auditory discrimination in the barn owl, J. Comp. Physiol. 186 (2000) 425-434.
[15] P. Montes-Lourido, M. Kar, I. Kumbam, S. Sadagopan, Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models, Sci. Rep. 11 (2021) 3108.
[16] H.-I. Liao, S. Kidani, M. Yoneya, M. Kashino, S. Furukawa, Correspondences among pupillary dilation response, subjective salience of sounds, and loudness, Psychon. Bull. Rev. 23 (2016) 412-425.
[17] A.D.S. Bala, E.A. Whitchurch, T.T. Takahashi, Human auditory detection and discrimination measured with the pupil dilation response, J. Assoc. Res. Otolaryngol. 21 (2020) 43-59.
[18] E. Selezneva, M. Brosch, S. Rathi, T. Vighneshvel, N. Wetzel, Comparison of pupil dilation responses to unexpected sounds in monkeys and humans, Front. Psychol. 12 (2021) 754604.
[19] J.L. Kleberg, T. Del Bianco, T. Falck-Ytter, How infants' arousal influences their visual search, Child Dev. 90 (2019) 1413-1423.
[20] M. Rudling, P. Nystro¨m, S. Bo¨lte, T. Falck-Ytter, Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis, JCPP 63 (2022) 793-801.
[21] N. Wetzel, D. Buttelmann, A. Schieler, A. Widmann, Infant and adult pupil dilation in response to unexpected sounds, Dev. Psychobiol. 58 (2016) 382-392.
[22] C. Bonmassar, A. Widmann, N. Wetzel, The impact of novelty and emotion on attention-related neuronal and pupil responses in children, Dev Cogn Neurosci 42 (2020) 100766.
[23] P.D. Fletcher, J.M. Nicholas, T.J. Shakespeare, L.E. Downey, H.L. Golden, J.L. Agustus, C.N. Clark, C.J. Mummery, J.M. Schott, S.J. Crutch, others, Physiological phenotyping of dementias using emotional sounds, Alzheim. Dement.: Diagn., Assess. Dis. Monit. 1 (2015) 170-178.
[24] P.D. Fletcher, J.M. Nicholas, T.J. Shakespeare, L.E. Downey, H.L. Golden, J.L. Agustus, C.N. Clark, C.J. Mummery, J.M. Schott, S.J. Crutch, others, Dementias show differential physiological responses to salient sounds, Front. Behav. Neurosci. 9 (2015) 73.
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[26] D. La Rosa, L. Bruschini, M.P. Tramonti Fantozzi, P. Orsini, M. Milazzo, A. Crivello, Pupil data upon stimulation by auditory stimuli, Data (Basel) 9 (2024) 43.
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BibTeX entry
@article{oai:iris.cnr.it:20.500.14243/552142,
title = {Challenges in using pupil dilation responses to sounds as a reliable alternative to standard audiometric tests},
author = {Tramonti Fantozzi M. P. and Crivello A. and La Rosa D. and Milazzo M. and Danti S. and De Cicco V. and Orsini P. and Manzoni D. and Lazzerini F. and Canelli R. and Fiacchini G. and Bruschini L.},
doi = {10.1016/j.heliyon.2025.e42666},
year = {2025}
}
0000-0001-7238-2181
APURE - Audiometry with PUpil REsponse
APURE - Audiometry with PUpil REsponse