2022
Journal article  Open Access

NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients

Borgheresi R., Barucci A., Colantonio S., Aghakhanyan G., Assante M., Bertelli E., Carlini E., Carpi R., Caudai C., Cavallero D., Cioni D., Cirillo R., Colcelli V., Dell'Amico A., Di Gangi D., Erba P. A., Faggioni L., Falaschi Z., Gabelloni M., Gini R., Lelii L., Liò P., Lorito A., Lucarini S., Manghi P., Mangiacrapa F., Marzi C., Mazzei M. A., Mercatelli L., Mirabile A., Mungai F., Miele V., Olmastroni M., Pagano P., Paiar F., Panichi G., Pascali M. A., Pasquinelli F., Shortrede J. E., Tumminello L., Volterrani L., Neri E., On Behalf Of The Navigator Consortium Group

Artificial Intelligence  Precision Medicine  Imaging Biobank  Biomarkers  Radiomics 

NAVIGATOR is an Italian regional project to boost precision medicine in oncology with the aim to make it more predictive, preventive, and personalised by advancing translational research based on quantitative imaging and integrative omics analyses. The project's goal is to develop an open imaging biobank for the collection and preservation of a large amount of standardised imaging multimodal datasets, including computed tomography, magnetic resonance imaging, and positron emission tomography data, together with the corresponding patient-related and omics-related relevant information extracted from regional healthcare services using an adapted privacy-preserving model. The project is based on an open-source imaging biobank and an open-science oriented virtual research environment (VRE). Available integrative omics and multi-imaging data of three use cases (prostate cancer, rectal cancer, and gastric cancer) will be collected. All data confined in NAVIGATOR (i.e. standard and novel imaging biomarkers, non-imaging data, health agency data) will be used to create a digital patient model, to support the reliable prediction of the disease phenotype and risk stratification. The VRE that relies on a well-established infrastructure, called D4Science.org, will further provide a multiset infrastructure for processing the integrative omics data, extracting specific radiomic signatures, and for identification and testing of novel imaging biomarkers through big data analytics and artificial intelligence.

Source: European radiology experimental Online 6 (2022). doi:10.1186/s41747-022-00306-9

Publisher: Springer Open, Svizzera

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BibTeX entry
@article{oai:it.cnr:prodotti:472886,
	title = {NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients},
	author = {Borgheresi R. and Barucci A. and Colantonio S. and Aghakhanyan G. and Assante M. and Bertelli E. and Carlini E. and Carpi R. and Caudai C. and Cavallero D. and Cioni D. and Cirillo R. and Colcelli V. and Dell'Amico A. and Di Gangi D. and Erba P. A. and Faggioni L. and Falaschi Z. and Gabelloni M. and Gini R. and Lelii L. and Liò P. and Lorito A. and Lucarini S. and Manghi P. and Mangiacrapa F. and Marzi C. and Mazzei M. A. and Mercatelli L. and Mirabile A. and Mungai F. and Miele V. and Olmastroni M. and Pagano P. and Paiar F. and Panichi G. and Pascali M. A. and Pasquinelli F. and Shortrede J. E. and Tumminello L. and Volterrani L. and Neri E. and On Behalf Of The Navigator Consortium Group},
	publisher = {Springer Open, Svizzera},
	doi = {10.1186/s41747-022-00306-9},
	journal = {European radiology experimental Online},
	volume = {6},
	year = {2022}
}

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