Efficacy of a Second PPI Course After Steroid-Induced Remission in Eosinophilic Esophagitis Refractory to Initial PPI Therapy
Visaggi P., Baiano Svizzero F., Del Corso G., Bellini M., Savarino E., De Bortoli N.
Proton Pump Inhibitors Humans EoE Enteritis Retrospective Studies Eosinophilia Proton Pump Inhibitors / therapeutic use Steroids / therapeutic use Eosinophilic Esophagitis Gastritis Steroids
INTRODUCTION:Eosinophilic esophagitis (EoE) requires maintenance therapy to avoid recurrence. We investigated the efficacy of a second course of proton pump inhibitors (scPPIs) to maintain steroid-induced histological remission (HR) in patients with EoE who had previously failed induction of remission with PPIs. METHODS:We retrospectively included 18 patients who achieved HR with topical steroids but could not be maintained on long-term topical steroids. Treatment outcomes were assessed after 12 weeks of scPPIs. RESULTS:Most of the patients (67%) maintained HR with high-dose PPI monotherapy at week 12. DISCUSSION:scPPIs might work as a maintenance strategy in primary PPI nonresponder EoE patients.
Source: THE AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 117 (issue 10), pp. 1702-1705
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@article{oai:it.cnr:prodotti:481748,
title = {Efficacy of a Second PPI Course After Steroid-Induced Remission in Eosinophilic Esophagitis Refractory to Initial PPI Therapy},
author = {Visaggi P. and Baiano Svizzero F. and Del Corso G. and Bellini M. and Savarino E. and De Bortoli N.},
doi = {10.14309/ajg.0000000000001943},
year = {2022}
}
0000-0003-4604-2006