WP1-CNR-ISTI - Ricostruzione di reti di regolazione genica da dati trascrittomici

Caudai C.

Gene regulation networks  Component separation 

Some recently proposed approaches to identify genetic regulatory mechanisms from sequencing experiments are briefly described. Since gene expression is influenced by biologica processes in the cell, and both the processes and the related transcription factors are largely unknown, many attempts have been made to solve this problem by blind source separation techniques. We analyse some of these approaches, each based on a linear data model.

Source: Project report, Bandiera InterOmics, 2014