Deep networks for behavioral variant frontotemporal dementia identification from multiple acquisition sources

Di Benedetto M., Carrara F., Tafuri B., Nigro S., De Blasi R., Falchi F., Gennaro C., Gigli G., Logroscino G., Amato G.

3D convolution  Behavioral variant frontotemporal dementia  bvFTD  Classification  Deep learning  Logistic regression  Machine learning  Medical imaging  Multi-layer perceptron  Neural networks  Transformer 

Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative syndrome whose clinical diagnosis remains a challenging task especially in the early stage of the disease. Currently, the presence of frontal and anterior temporal lobe atrophies on magnetic resonance imaging (MRI) is part of the diagnostic criteria for bvFTD. However, MRI data processing is usually dependent on the acquisition device and mostly require human-assisted crafting of feature extraction. Following the impressive improvements of deep architectures, in this study we report on bvFTD identification using various classes of artificial neural networks, and present the results we achieved on classification accuracy and obliviousness on acquisition devices using extensive hyperparameter search. In particular, we will demonstrate the stability and generalization of different deep networks based on the attention mechanism, where data intra-mixing confers models the ability to identify the disorder even on MRI data in inter-device settings, i.e., on data produced by different acquisition devices and without model fine tuning, as shown from the very encouraging performance evaluations that dramatically reach and overcome the 90% value on the AuROC and balanced accuracy metrics.

Source: Computers in biology and medicine 148 (2022). doi:10.1016/j.compbiomed.2022.105937

Publisher: Pergamon,, Oxford etc. , Regno Unito

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